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ASCP MLS PRACTICES EXAM — 2026
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ALL MCQS IN PRACTICE TEST

Question21:-Hemoglobin resulting from a mutation where lysine is substituted for
glutamate in the sixth position of the β-globin chain
A:-Hemoglobin A
B:-Hemoglobin F
C:-Hemoglobin C
D:-Hemoglobin S
Correct Answer:- Option-C
Question22:-Shipment of frozen HSC product is made in a secondary container to
prevent leakage and contamination. The temperature is continuously monitored
and maintained at or below
A:-minus 80ºC
B:-zero ºC
C:-10°C
D:-minus 150ºC
Correct Answer:- Option-D

Question23:-Fever of a non-infectious origin, which develops when white cell count
increases HSC post transplant. Classical features include fever >38.3º C, skin rash,
non cardiogenic pulmonary edema or hypoxia, or a sudden increase in CRP values
>20mg/dL. This is known as
A:-FNHTR
B:-Job’s syndrome
C:-Engraftment syndrome
D:-Lazy leucocyte syndrome
Correct Answer:- Option-C
Question24:-Which of the following is FDA approved CAR-T cells ?
A:-Tisagenlecleucel (Kymriah)
B:-Humate P
C:-Both
D:-None of the above
Correct Answer:- Option-A
Question25:-X linked recessive pattern of inheritance is seen in
A:
Blood group system
B:-Hemophilia A
C:-XK gene
D:-Both 2 and 3
Correct Answer:- Option-D

Question26:-1-4 Butane Diol Wax
A:-is a leaching agent
B:-is a cryoprotectant
C:-is used to bring down the temperature of collected blood to 20ºC
D:-is a rejuvenating agent
Correct Answer:- Option-C
Question27:-Minimum haematocrit of PRBC in SAGM should be
A:-65-70%
B:-60-70%
C:-50-60%
D:-65-75%
Correct Answer:- Option-C
Question28:-Red cells washed in a closed system have an expiry time of
A:-24 hours
B:-14 days
C:-6 hours
D:-none of the above
Correct Answer:- Option-B
Question29:-Most commonly used cryopreservation method by Glycerol is
A:-Low concentration glycerol with rapid freezing
B:-Low concentration glycerol with slow freezing
C:-High concentration glycerol with slow freezing
D:-High concentration glycerol with rapid freezing
Correct Answer:- Option-C
Question30:-Method of pathogen inactivation that does not affect coagulation and
anti thrombotic factors
A:-Methylene blue
B:-Psoralen UV-A
C:-Riboflavin
D:-Solvent detergent
Correct Answer:-Question Cancelled

ASCP Q31:-In the risk stratification for emerging viral infections, chikungunya is
classified under
A:-Red
B:-Orange
C:-Yellow
D:-White
Correct Answer:- Option-B
Question32:-The titre of which antibody is known to wean off in the serum of as
immunised person
A:-Anti kidd
B:-Anti Kell
C:-Anti c
D:-Anti S
Correct Answer:- Option-A
Question33:-Pick out the false statement :
A:-Lw antigen is a low frequency antigen
B:-Duffy blood group antibodies are capable of producing severe extravascular
haemolytic reactions
C:-Next to ABO and Rh blood groups, kell antigen is the most immunogenic
D:-Kell antigen is destroyed by DTT
Correct Answer:- Option-A
Question34:-Severity of anaemia in HDFN caused by which blood group, antibodies
is much more pronounced than other blood group antibodies
A:-Anti Kidd
B:-Anti D
C:-Anti Kell
D:-Anti Duffy
Correct Answer:- Option-C
Question35:-Definition of massive transfusion and its indications are all except
A:-Transfusion of three or more blood units in one hour
B:-Transfusion of 10 or more blood units in 24 hours
C:-Replacement of 50% of blood volume in 3-4 hours
D:-Blood loss at the rate 150 ml per hour or more
Correct Answer:- Option-D
Question36:-Pick out the false statement :
A:-Leucapheresis quickly decreases the burden of circulating WBC
B:-Leucapheresis prolongs the S and G2/M phase of leukemia
C:-Clinical signs and symptoms of leucocytosis develop in more than 10% of
ALL patients
D:-Leucapheresis improves response of proliferating cells to chemotherapy
Correct Answer:- Option-C
Question37:-All immunoadsorption columns can be used in a patient on ACE 1
inhibitor (Angiotensin Converting Enzyme) except
A:-Cholesterol
B:-Sheep antihuman immunoglobulin
C:-Phenylalanine
D:-Tryptophan
Correct Answer:- Option-D
Question38:-Pick out the wrong statement regarding West Nile Virus :
A:-Usually patients over 50 suffer from severe disease
B:-A common cause of death in the elderly is encephalitis
C:-Around 38% of infected individuals die succumb to disease
D:-One out of 150 patients suffer from severe CNS disease
Correct Answer:- Option-C
Question39:-Vertical transmission is most frequent in
A:-HIV
B:-HBV
C:-CMV
D:-EBV
Correct Answer:- Option-C
Question40:-The most common immune cause of platelet refractoriness is
A:-Anticomplement antibodies
B:-Antibodies to class II HLA antigens
C:-Cytokines
D:-Antibodies to class I HLA antigens
Correct Answer:- Option-D

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